Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADA | P00813 | 13/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.40 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848612 | 0.87 | ADA (0.60) | ADAHDAC3HDAC1HDAC6 | |
| SCHEMBL7846603 | 0.77 | ADA (0.54) | ADAHDAC3HDAC1HDAC6HDAC2 | |
| SCHEMBL9478816 | 0.76 | ADA (0.59) | ADAHDAC3HDAC1HDAC6NPC1 | |
| SCHEMBL7847122 | 0.75 | ADA (0.50) | ADAHDAC3HDAC1HDAC6NPC1 | |
| SCHEMBL9806732 | 0.75 | ADA (0.58) | ADAHDAC3HDAC1HDAC6NPC1 | |
| SCHEMBL7850108 | 0.74 | ADA (0.39) | ADANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6942802 | 0.74 | ADA (1.00) | ADA | |
| SCHEMBL7836409 | 0.74 | ADA (0.58) | ADA | |
| SCHEMBL7845082 | 0.72 | ADA (0.38) | ADA | |
| SCHEMBL7850442 | 0.72 | ADA (0.49) | ADA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161429-A2 | HETEROCYCLIC COMPOUNDS AS ADENOSINE DEAMINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055155-A2 | HETEROCYCLIC COMPOUNDS AS ADENOSINE DEAMINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-09-21 | — | — | WO | disclosed |