Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824788 | 1.00 | HTR6 (0.57) | HTR6OPRL1TAAR1DPP4CHRNA7 | |
| SCHEMBL31011763 | 0.94 | HTR6 (0.62) | HTR6OPRL1TAAR1DPP4CHRNA7 | |
| Hydrochloric Acid SCHEMBL6421115 | 0.93 | HTR6 (0.60) | HTR6OPRL1TAAR1DPP4CHRNA7 | |
| SCHEMBL29332421 | 0.89 | HTR6 (0.53) | HTR6OPRL1TAAR1DPP4CHRNA7 | |
| SCHEMBL9940114 | 0.79 | TAAR1 (0.46) | HTR6TAAR1ADRB1HPGDKMT2A | |
| SCHEMBL7814997 | 0.78 | CHRNA7 (0.43) | HTR6OPRL1DPP4CHRNA7SMN1; SMN2 | |
| SCHEMBL29675238 | 0.77 | OPRL1 (0.45) | HTR6OPRL1DPP4CHRNA7KMT2A | |
| SCHEMBL6002215 | 0.77 | OPRL1 (0.45) | HTR6OPRL1DPP4CHRNA7KMT2A | |
| SCHEMBL14671269 | 0.75 | HTR6 (0.60) | HTR6OPRL1ADRB1 | |
| SCHEMBL14667905 | 0.75 | HTR6 (0.60) | HTR6ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140891-A1 | 1,4-DIAZACYCLOHEPTANE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040574-A1 | 1,4-DIAZACYCLOHEPTANE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2000-07-13 | — | — | WO | disclosed |