Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002215 | 0.94 | OPRL1 (0.45) | CHRNA7OPRL1HTR6DPP4CHRM2 | |
| SCHEMBL29675238 | 0.94 | OPRL1 (0.45) | CHRNA7OPRL1HTR6DPP4CHRM2 | |
| SCHEMBL7832801 | 0.83 | OPRL1 (0.40) | CHRNA7OPRL1HTR6DPP4HTR2B | |
| SCHEMBL7827208 | 0.78 | HCRTR1 (0.54) | OPRL1ADRA2BADRA2CSMN1; SMN2CYP2D6 | |
| SCHEMBL7837293 | 0.78 | HTR6 (0.57) | CHRNA7OPRL1HTR6DPP4SMN1; SMN2 | |
| SCHEMBL7824788 | 0.78 | HTR6 (0.57) | CHRNA7OPRL1HTR6DPP4SMN1; SMN2 | |
| SCHEMBL7831739 | 0.77 | SIGMAR1 (0.39) | OPRL1HTR6DPP4 | |
| SCHEMBL31011763 | 0.77 | HTR6 (0.62) | CHRNA7OPRL1HTR6DPP4HTR2A | |
| SCHEMBL7814725 | 0.76 | POLB (0.54) | OPRL1SMN1; SMN2TSHRCYP2C19 | |
| Hydrochloric Acid SCHEMBL6421115 | 0.75 | HTR6 (0.60) | CHRNA7OPRL1HTR6DPP4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140891-A1 | 1,4-DIAZACYCLOHEPTANE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040574-A1 | 1,4-DIAZACYCLOHEPTANE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2000-07-13 | — | — | WO | disclosed |