Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 14/20 | 0.71 |
| ▸ | KDR | P35968 | 13/20 | 0.71 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.71 |
| ▸ | SRC | P12931 | 7/20 | 0.71 |
| ▸ | EGFR | P00533 | 3/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837476 | 1.00 | PDGFRB (0.71) | PDGFRBKDRFGFR1SRCEGFR | |
| SCHEMBL8205880 | 0.92 | PDGFRB (0.72) | PDGFRBKDRFGFR1SRCEGFR | |
| SCHEMBL8205878 | 0.92 | PDGFRB (0.72) | PDGFRBKDRFGFR1SRCEGFR | |
| SCHEMBL8211103 | 0.86 | PDGFRB (0.72) | PDGFRBKDRFGFR1SRCEGFR | |
| SCHEMBL7825508 | 0.86 | PDGFRB (0.72) | PDGFRBKDRFGFR1SRCEGFR | |
| SCHEMBL6393305 | 0.83 | FGFR1 (1.00) | PDGFRBKDRFGFR1SRCEGFR | |
| SCHEMBL6393309 | 0.83 | FGFR1 (1.00) | PDGFRBKDRFGFR1SRCEGFR | |
| SCHEMBL6701476 | 0.77 | SRC (0.78) | PDGFRBKDRFGFR1SRCEGFR | |
| SCHEMBL6391952 | 0.76 | FGFR1 (1.00) | PDGFRBKDRFGFR1SRCEGFR | |
| SCHEMBL6391950 | 0.76 | FGFR1 (1.00) | PDGFRBKDRFGFR1SRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066257-A2 | HETEROCYLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | Sugen, Inc. (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999048868-A2 | HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | SUGEN, INC. (US) | 1999-09-30 | — | — | WO | disclosed |