Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 12/20 | 0.72 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.72 |
| ▸ | KDR | P35968 | 10/20 | 0.72 |
| ▸ | SRC | P12931 | 9/20 | 0.72 |
| ▸ | EGFR | P00533 | 3/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8211103 | 1.00 | PDGFRB (0.72) | PDGFRBFGFR1KDRSRCEGFR | |
| SCHEMBL7837474 | 0.86 | PDGFRB (0.71) | PDGFRBFGFR1KDRSRCEGFR | |
| SCHEMBL7837476 | 0.86 | PDGFRB (0.71) | PDGFRBFGFR1KDRSRCEGFR | |
| SCHEMBL8205878 | 0.85 | PDGFRB (0.72) | PDGFRBFGFR1KDRSRCEGFR | |
| SCHEMBL8205880 | 0.85 | PDGFRB (0.72) | PDGFRBFGFR1KDRSRCEGFR | |
| SCHEMBL6392692 | 0.84 | FGFR1 (1.00) | PDGFRBFGFR1KDRSRCEGFR | |
| SCHEMBL6392695 | 0.84 | FGFR1 (1.00) | PDGFRBFGFR1KDRSRCEGFR | |
| SCHEMBL7834370 | 0.82 | PDGFRB (1.00) | PDGFRBFGFR1KDRSRCEGFR | |
| SCHEMBL7834368 | 0.82 | PDGFRB (1.00) | PDGFRBFGFR1KDRSRCEGFR | |
| SCHEMBL3718409 | 0.79 | KDR (0.73) | PDGFRBFGFR1KDRSRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066257-A2 | HETEROCYLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | Sugen, Inc. (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999048868-A9 | HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | SUGEN INC (US) | 2000-04-20 | — | — | WO | disclosed |
| WO-1999048868-A2 | HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE | SUGEN, INC. (US) | 1999-09-30 | — | — | WO | disclosed |