Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CD69 | Q07108 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15061388 | 1.00 | SIGMAR1 (0.39) | SIGMAR1OPRM1DPP9DPP7KDM1A | |
| SCHEMBL380064 | 0.78 | OPRM1 (0.38) | SIGMAR1OPRM1KDM1A | |
| Hydrochloric Acid SCHEMBL6669828 | 0.75 | HTR2A (0.36) | SIGMAR1OPRM1DPP9DPP7KDM1A | |
| SCHEMBL30573675 | 0.71 | MCHR2 (0.46) | SIGMAR1KDM1AALOX15HTR2ADRD2 | |
| SCHEMBL4975811 | 0.71 | MCHR2 (0.46) | SIGMAR1KDM1AALOX15HTR2ADRD2 | |
| Hydrochloric Acid SCHEMBL6973147 | 0.70 | MCHR2 (0.45) | SIGMAR1KDM1AALOX15HTR2ADRD2 | |
| Hydrochloric Acid SCHEMBL6976186 | 0.70 | MCHR2 (0.45) | SIGMAR1KDM1AALOX15HTR2ADRD2 | |
| SCHEMBL379939 | 0.70 | SIGMAR1 (0.37) | SIGMAR1KDM1AHTR2AHTR2C | |
| SCHEMBL379938 | 0.70 | SIGMAR1 (0.37) | SIGMAR1KDM1AHTR2AHTR2C | |
| SCHEMBL21383813 | 0.70 | KDM1A (0.53) | SIGMAR1OPRM1DPP9DPP7KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476253-B2 | Amide derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-02 | — | — | US | disclosed |
| US-8476253-B2 | Amide derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-02 | — | — | US | disclosed |
| US-20120071467-A1 | AMIDE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
| US-20120071467-A1 | AMIDE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
| WO-2010106988-A1 | AMIDE DERIVATIVE | 第一三共株式会社 (JP) | 2010-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071467-A1 | AMIDE DERIVATIVE | CHRM3, CHRM2, TACR2 | SIGMAR1 116/4885OPRM1 15/4885DPP9 2016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.