Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25041388 | 0.87 | PDGFRA (0.54) | NOTUMSYKADORA2APDGFRAKDM4E | |
| SCHEMBL29218636 | 0.78 | SYK (0.54) | NOTUMSYKADORA2APDGFRAKDM4E | |
| SCHEMBL8811827 | 0.77 | HRH3 (0.54) | NOTUMKDM4EALDH1A1MAPK1DRD2 | |
| SCHEMBL25042175 | 0.76 | GPR119 (0.48) | SYKALDH1A1MAPK1DRD2DRD3 | |
| SCHEMBL4341894 | 0.75 | NOTUM (0.78) | NOTUMKDM4EALDH1A1MAPK1DRD2 | |
| SCHEMBL7425143 | 0.74 | NOTUM (0.51) | NOTUMKDM4EALDH1A1MAPK1DRD2 | |
| SCHEMBL11526739 | 0.73 | MAPT (0.63) | KDM4EALDH1A1MAPK1POLBMAPT | |
| SCHEMBL11117073 | 0.73 | NOTUM (0.58) | NOTUMKDM4EALDH1A1MAPK1POLB | |
| SCHEMBL28042938 | 0.73 | NOTUM (0.63) | NOTUMKDM4EALDH1A1MAPK1DRD2 | |
| SCHEMBL28205331 | 0.73 | NOTUM (0.58) | NOTUMSYKKDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080092-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999061444-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-12-02 | — | — | WO | disclosed |