Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.36 |
| ▸ | MDM4 | O15151 | 2/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342043 | 0.89 | PIN1 (0.55) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL7337769 | 0.85 | POLB (0.44) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL7825718 | 0.85 | TP53 (0.47) | MEN1KMT2ATP53GPR139MDM4 | |
| SCHEMBL7341748 | 0.82 | TACR1 (0.41) | MEN1KMT2ATP53GPR139MDM4 | |
| SCHEMBL7838138 | 0.81 | POLB (0.37) | NPC1RAB9AMEN1KMT2ATP53 | |
| SCHEMBL7835741 | 0.81 | MEN1 (0.40) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL7341105 | 0.81 | CTSL (0.46) | MEN1KMT2ATP53GPR139 | |
| SCHEMBL7340345 | 0.81 | TP53 (0.39) | NPC1RAB9ATP53GPR139ITGB3 | |
| SCHEMBL7340072 | 0.80 | POLB (0.38) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7344058 | 0.80 | GLA (0.41) | NPC1RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |