Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.48 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848302 | 0.89 | POLB (0.55) | TLR8POLBCYP1A2CYP2D6HTT | |
| SCHEMBL7847769 | 0.83 | HTT (0.57) | TLR8POLBCYP1A2CYP2D6HTT | |
| SCHEMBL2994706 | 0.76 | TLR8 (0.68) | TLR8POLBCYP1A2CYP2D6HTT | |
| SCHEMBL1980314 | 0.76 | HSD17B10 (0.57) | POLBCYP1A2CYP2D6HTTCXCR4 | |
| SCHEMBL21310919 | 0.75 | KDM4E (0.57) | TLR8POLBCYP1A2CYP2D6HTT | |
| SCHEMBL7847984 | 0.74 | NOS2 (0.55) | TLR8POLBCYP1A2CYP2D6HTT | |
| Bromide SCHEMBL1982279 | 0.74 | HSD17B10 (0.56) | POLBCYP1A2CYP2D6HTTCXCR4 | |
| SCHEMBL1170110 | 0.74 | TLR8 (1.00) | TLR8POLBCYP1A2CYP2D6HTT | |
| SCHEMBL16329007 | 0.73 | TLR8 (0.47) | TLR8POLBHTTASAH1TLR7 | |
| SCHEMBL16512992 | 0.73 | TLR8 (1.00) | TLR8POLBCYP1A2CYP2D6HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091942-A1 | POTASSIUM CHANNEL BLOCKING AGENTS | NEUROSEARCH A/S (DK) | 2001-04-18 | — | — | EP | claimed |
| WO-2000001676-A1 | POTASSIUM CHANNEL BLOCKING AGENTS | NEUROSEARCH A/S (DK) | 2000-01-13 | — | — | WO | claimed |
| EP-1091942-A1 | POTASSIUM CHANNEL BLOCKING AGENTS | NEUROSEARCH A/S (DK) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001676-A1 | POTASSIUM CHANNEL BLOCKING AGENTS | NEUROSEARCH A/S (DK) | 2000-01-13 | — | — | WO | disclosed |