Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.51 |
| ▸ | NOS2 | P35228 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 3/20 | 0.43 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.43 |
| ▸ | TNF | P01375 | 2/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848302 | 0.87 | POLB (0.55) | HTTCYP1A2CYP2D6POLBTLR8 | |
| SCHEMBL21310919 | 0.85 | KDM4E (0.57) | HTTCYP1A2CYP2D6POLBTLR8 | |
| SCHEMBL7837738 | 0.83 | TLR8 (0.58) | HTTCYP1A2CYP2D6POLBTLR8 | |
| SCHEMBL1980314 | 0.82 | HSD17B10 (0.57) | HTTCYP1A2CYP2D6POLBNOS2 | |
| SCHEMBL7847984 | 0.80 | NOS2 (0.55) | HTTCYP1A2CYP2D6POLBTLR8 | |
| Bromide SCHEMBL1982279 | 0.80 | HSD17B10 (0.56) | HTTCYP1A2CYP2D6POLBNOS2 | |
| SCHEMBL8564481 | 0.78 | CYP1A2 (0.55) | HTTCYP1A2CYP2D6POLBTLR8 | |
| SCHEMBL30319490 | 0.77 | NOS2 (0.55) | HTTCYP1A2CYP2D6POLBTLR8 | |
| SCHEMBL4581653 | 0.75 | NOS2 (0.49) | HTTCYP1A2CYP2D6POLBTLR8 | |
| SCHEMBL6930941 | 0.75 | CYP1A2 (0.51) | HTTCYP1A2CYP2D6POLBTLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091942-A1 | POTASSIUM CHANNEL BLOCKING AGENTS | NEUROSEARCH A/S (DK) | 2001-04-18 | — | — | EP | claimed |
| WO-2000001676-A1 | POTASSIUM CHANNEL BLOCKING AGENTS | NEUROSEARCH A/S (DK) | 2000-01-13 | — | — | WO | claimed |
| EP-1091942-A1 | POTASSIUM CHANNEL BLOCKING AGENTS | NEUROSEARCH A/S (DK) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001676-A1 | POTASSIUM CHANNEL BLOCKING AGENTS | NEUROSEARCH A/S (DK) | 2000-01-13 | — | — | WO | disclosed |