Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 9/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.39 |
| ▸ | FLT1 | P17948 | 6/20 | 0.39 |
| ▸ | FLT4 | P35916 | 6/20 | 0.39 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 3/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | STK10 | O94804 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847135 | 0.87 | KDR (0.45) | KDRRETEGFRFLT4MET | |
| SCHEMBL5682902 | 0.85 | KDR (0.46) | KDRTRPA1RETEGFRFGFR1 | |
| SCHEMBL2958541 | 0.77 | EGFR (0.54) | KDRRETEGFRFGFR1FLT1 | |
| SCHEMBL7845204 | 0.77 | KDR (0.45) | KDRRETEGFRMETLCK | |
| SCHEMBL7846902 | 0.76 | KDR (0.45) | KDRRETEGFRMETLCK | |
| SCHEMBL4384046 | 0.75 | KDR (0.41) | KDRRETEGFRFLT4MET | |
| SCHEMBL3193673 | 0.75 | KDR (0.65) | KDRRETEGFRFGFR1FLT1 | |
| SCHEMBL4375533 | 0.75 | KDR (0.61) | KDRRETEGFRFGFR1FLT1 | |
| SCHEMBL2957427 | 0.75 | ABCB11 (0.65) | KDRRETEGFRFGFR1FLT1 | |
| SCHEMBL6366468 | 0.75 | KDR (0.43) | KDRRETEGFRFLT4MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154774-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047212-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-17 | — | — | WO | disclosed |