Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.62 |
| ▸ | MGLL | Q99685 | 2/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | STS | P08842 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14655033 | 0.86 | MEN1 (0.63) | GPR119MGLLHSD11B1KMT2ASTS | |
| SCHEMBL2328921 | 0.86 | USP30 (0.53) | GPR119KMT2AMEN1PKM | |
| SCHEMBL2328924 | 0.86 | USP30 (0.53) | GPR119KMT2AMEN1PKM | |
| SCHEMBL441012 | 0.85 | KDM4E (0.62) | GPR119MGLLHSD11B1KMT2ASTS | |
| SCHEMBL17594737 | 0.85 | STS (0.55) | GPR119KMT2ASTSMEN1PTPN2 | |
| SCHEMBL23411161 | 0.85 | KMT2A (0.76) | GPR119KMT2ASTSMEN1PTPN2 | |
| SCHEMBL29967193 | 0.85 | KMT2A (0.76) | GPR119KMT2ASTSMEN1PTPN2 | |
| SCHEMBL10966317 | 0.85 | MGLL (0.59) | MGLLHSD11B1KMT2AMEN1KDM4E | |
| SCHEMBL5245718 | 0.84 | NPC1 (0.54) | GPR119MGLLKMT2ASTSMEN1 | |
| SCHEMBL16225262 | 0.84 | HSD11B1 (0.60) | MGLLHSD11B1KMT2ASTSMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| US-5891889-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |