Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC15A1 | P46059 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.55 |
| ▸ | LAP3 | P28838 | 3/20 | 0.55 |
| ▸ | ANPEP | P15144 | 1/20 | 0.55 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.55 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.55 |
| ▸ | ALPI | P09923 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | XIAP | P98170 | 1/20 | 0.55 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2232612 | 0.94 | SLC6A2 (0.61) | SLC15A1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL29941240 | 0.94 | SLC6A2 (0.61) | SLC15A1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL6191623 | 0.94 | SLC6A2 (0.61) | SLC15A1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL6193282 | 0.94 | SLC6A2 (0.61) | SLC15A1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL8091553 | 0.94 | SLC6A2 (0.61) | SLC15A1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL23752456 | 0.94 | SLC6A2 (0.61) | SLC15A1SLC6A2TAAR1MAOASLC6A4 | |
| Hydrochloric Acid SCHEMBL27535848 | 0.92 | SLC6A2 (0.59) | SLC15A1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL8561050 | 0.81 | ALPI (0.60) | SLC15A1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL7959353 | 0.79 | ALPI (0.58) | SLC15A1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL6321788 | 0.79 | ALPI (0.58) | SLC15A1SLC6A2TAAR1MAOASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0778827-B1 | PROCESS FOR PRODUCING A BETA-AMINO ALCOHOL | DEGUSSA (DE) | 2001-12-12 | — | — | EP | disclosed |