Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7218658 | 0.75 | NR4A2 (0.59) | NR4A2LMNAGAAHTTTSHR | |
| SCHEMBL7839279 | 0.75 | NR4A2 (0.59) | NR4A2LMNAGAAHTTTSHR | |
| SCHEMBL5237030 | 0.75 | NR4A2 (0.59) | NR4A2LMNAGAAHTTTSHR | |
| SCHEMBL29217694 | 0.72 | NR4A2 (0.43) | NR4A2LMNAGAAHTTTSHR | |
| SCHEMBL20842473 | 0.70 | TGFBR1 (0.49) | TSHRKMT2AMEN1KDM4ECCR1 | |
| SCHEMBL29163735 | 0.70 | L3MBTL1 (0.52) | KMT2AMEN1ALDH1A1KDM4ECCR1 | |
| SCHEMBL16502656 | 0.70 | TGFBR1 (0.46) | LMNAGAAHTTKMT2AMEN1 | |
| SCHEMBL7839162 | 0.70 | NR4A2 (0.49) | NR4A2LMNAKMT2AMEN1MAPT | |
| SCHEMBL10717437 | 0.69 | HTT (0.67) | NR4A2LMNAGAAHTTTSHR | |
| SCHEMBL28490176 | 0.69 | KDM4E (0.45) | LMNAHTTKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140946-A2 | QUINOLINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035919-A2 | QUINOLINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2000-06-22 | — | — | WO | disclosed |