Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6293942 | 0.90 | KMT2A (0.64) | ROCK2CYP3A4ROCK1MEN1KMT2A | |
| SCHEMBL7843437 | 0.88 | ROCK2 (0.58) | ROCK2CYP3A4ROCK1 | |
| SCHEMBL6293583 | 0.88 | MAPT (0.59) | ROCK2CYP3A4ROCK1MEN1KMT2A | |
| SCHEMBL6295130 | 0.86 | NR1H4 (0.56) | ROCK2CYP3A4ROCK1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8110344 | 0.85 | TMPRSS2 (0.65) | ROCK2CYP3A4ROCK1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6294914 | 0.85 | TMPRSS2 (0.65) | ROCK2CYP3A4ROCK1MEN1KMT2A | |
| SCHEMBL6293601 | 0.84 | TRPV1 (0.71) | ROCK2CYP3A4ROCK1MEN1KMT2A | |
| SCHEMBL6293747 | 0.84 | TP53 (0.61) | ROCK2CYP3A4ROCK1KMT2ATMPRSS2 | |
| SCHEMBL6299395 | 0.84 | PKM (0.56) | ROCK2CYP3A4ROCK1MEN1KMT2A | |
| SCHEMBL6293540 | 0.83 | NR1H4 (0.55) | ROCK2CYP3A4ROCK1TMPRSS2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010016657-A1 | Substituted isoquinoline derivatives and their use as anticonvulsants | SMITHKLINE BEECHAM P.L.C. | 2001-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010016657-A1 | Substituted isoquinoline derivatives and their use as anticonvulsants | INA, GRIN2C, GRIN2A | ROCK2 2314/4885CYP3A4 168/4885ROCK1 3641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.