Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 15/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.34 |
| ▸ | PTPRC | P08575 | 4/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 5/20 | 0.33 |
| ▸ | PTPN6 | P29350 | 5/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.33 |
| ▸ | PTPRB | P23467 | 3/20 | 0.33 |
| ▸ | CDC25A | P30304 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | PGK2 | P07205 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6941207 | 0.83 | PTPN1 (0.62) | PTPN1PTPN5PTPRCPTPN2PTPN6 | |
| SCHEMBL6941229 | 0.81 | PTPN1 (0.41) | PTPN1PTPRCPTPN2PTPN6PTPN11 | |
| SCHEMBL6943956 | 0.75 | PTPN1 (0.39) | PTPN1PTPN5PTPRCPTPN2PTPN6 | |
| SCHEMBL6941175 | 0.75 | PTPN1 (0.59) | PTPN1PTPRCPTPN2PTPN6PTPN11 | |
| SCHEMBL6944028 | 0.74 | PTPN1 (0.52) | PTPN1PTPN5PTPRCPTPN2PTPN6 | |
| SCHEMBL6946050 | 0.74 | PTPN1 (0.52) | PTPN1PTPRCPTPN2PTPN6PTPN11 | |
| SCHEMBL6944034 | 0.73 | PTPN1 (0.51) | PTPN1PTPN5PTPRCPTPN2PTPN6 | |
| SCHEMBL7886902 | 0.72 | PTPN1 (0.43) | PTPN1PTPRCPTPN2PTPN6 | |
| SCHEMBL7592325 | 0.72 | PTPN1 (0.50) | PTPN1PTPRCPTPN2PTPN6PTPN11 | |
| SCHEMBL7886828 | 0.72 | PTPN1 (0.55) | PTPN1PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115729-A1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | Merck Frosst Canada & Co. (CA) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017211-A1 | PHOSPHONIC ACIDS DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA & CO. (CA) | 2000-03-30 | — | — | WO | disclosed |