Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7845532 | 0.90 | MEN1 (0.52) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7831653 | 0.88 | PKM (0.53) | PKMOPRD1OPRK1MEN1KMT2A | |
| SCHEMBL1002715 | 0.87 | PKM (0.55) | PKMOPRD1OPRK1TACR1STS | |
| SCHEMBL7830298 | 0.85 | PKM (0.51) | PKMOPRD1OPRK1ALDH1A1STS | |
| SCHEMBL31603001 | 0.84 | PKM (0.46) | PKMOPRD1OPRK1MEN1KMT2A | |
| SCHEMBL7838076 | 0.82 | PKM (0.46) | PKMMEN1KMT2ATACR1L3MBTL1 | |
| SCHEMBL31603137 | 0.81 | PKM (0.48) | PKMOPRD1OPRK1MEN1KMT2A | |
| SCHEMBL31602934 | 0.81 | PKM (0.48) | PKMOPRD1OPRK1MEN1KMT2A | |
| SCHEMBL2375967 | 0.81 | PKM (0.56) | PKMOPRD1OPRK1ALDH1A1TACR1 | |
| SCHEMBL7838073 | 0.80 | PKM (0.45) | PKMOPRD1OPRK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| US-5891889-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |