Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840611 | 0.90 | PKM (0.52) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL22789557 | 0.89 | MEN1 (0.53) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL22309108 | 0.88 | MEN1 (0.68) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL965515 | 0.87 | LMNA (0.62) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7842534 | 0.85 | KMT2A (0.48) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7838476 | 0.84 | MEN1 (0.54) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7840126 | 0.84 | MEN1 (0.50) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL8185447 | 0.84 | KMT2A (0.57) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7842531 | 0.83 | KMT2A (0.47) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7829838 | 0.83 | PKLR (0.48) | MEN1KMT2AALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| US-5891889-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |