Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.56 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11625886 | 0.88 | ALDH1A1 (0.59) | MEN1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL11627969 | 0.86 | HSD17B2 (0.58) | MEN1KMT2AALDH1A1CA1CA2 | |
| SCHEMBL11630192 | 0.86 | KMT2A (0.59) | MEN1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL11628551 | 0.82 | BACE1 (0.58) | MEN1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL11627202 | 0.82 | RAB9A (0.48) | MEN1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL11626484 | 0.82 | NPC1 (0.71) | KMT2AALDH1A1RAB9ANPC1CA1 | |
| SCHEMBL5860896 | 0.82 | ALDH1A1 (0.73) | MEN1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL7285179 | 0.82 | ALDH1A1 (0.73) | MEN1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL16082991 | 0.81 | ALDH1A1 (0.83) | MEN1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL28992291 | 0.79 | ALDH1A1 (0.68) | MEN1KMT2AALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144381-A2 | SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GmbH (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000032577-A2 | SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GMBH (DE) | 2000-06-08 | — | — | WO | disclosed |