Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | EDNRA | P25101 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8152135 | 0.85 | KMT2A (0.57) | LMNAEDNRANPC1RAB9AMAPT | |
| SCHEMBL7841290 | 0.83 | RAB9A (0.46) | L3MBTL1NPC1RAB9AMAPTKMT2A | |
| SCHEMBL27378630 | 0.82 | CYP3A4 (0.43) | LMNANPC1RAB9AMAPTKMT2A | |
| SCHEMBL7842489 | 0.81 | RAB9A (0.44) | L3MBTL1NPC1RAB9AMAPTKMT2A | |
| SCHEMBL7831716 | 0.81 | RAB9A (0.44) | LMNANPC1RAB9AMAPTKMT2A | |
| SCHEMBL7839027 | 0.81 | KDM4E (0.49) | LMNANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7840091 | 0.81 | CRHBP (0.47) | LMNANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7838582 | 0.81 | MAPT (0.55) | LMNAL3MBTL1NPC1RAB9AMAPT | |
| SCHEMBL7843720 | 0.80 | KDM4E (0.44) | LMNANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7842082 | 0.80 | NPC1 (0.44) | L3MBTL1NPC1RAB9AMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1072660-C | 2,1,3-benzothia (oxa) diazole derivatives having an endothelin receptor antagonistic effect | MERCK PATENT GMBH (DE) | 2001-10-10 | — | — | CN | disclosed |
| EP-0882030-B1 | 2,1,3-BENZOTHIA(OXA)DIAZOLE DERIVATIVES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT | MERCK PATENT GMBH (DE) | 2001-09-12 | — | — | EP | disclosed |
| US-6017939-A | 2,1,3-benzothia(OXA)diazole derivatives having an endothelin receptor antagonistic effect | MERCK PATENT GESELLSCHAFT (DE) | 2000-01-25 | — | — | US | disclosed |
| CN-1216540-A | 2,1,3-benzothia (oxa) diazole derivatives having an endothelin receptor antagonistic effect | MERCK PATENT GES MIT BESCHRIKT (DE) | 1999-05-12 | — | — | CN | disclosed |