Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | PPIA | P62937 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23633289 | 0.83 | KMT2A (0.63) | KMT2AMEN1LMNAMAPTTSHR | |
| SCHEMBL367886 | 0.82 | KMT2A (0.61) | KMT2AMEN1LMNAMAPTGAA | |
| Hydrochloric Acid SCHEMBL29012769 | 0.81 | KMT2A (0.59) | KMT2AMEN1LMNAMAPTGAA | |
| SCHEMBL9813388 | 0.78 | KMT2A (0.48) | KMT2AGAATSHRCYP1A2CYP2C19 | |
| SCHEMBL7439749 | 0.78 | POLB (0.50) | KMT2AMEN1LMNAMAPTGAA | |
| SCHEMBL28603753 | 0.77 | KMT2A (0.54) | KMT2AMEN1LMNAMAPTGAA | |
| SCHEMBL1007576 | 0.76 | MAPT (0.62) | KMT2AMEN1LMNAMAPTGAA | |
| Bromomethane SCHEMBL5884083 | 0.75 | KMT2A (0.61) | KMT2AMEN1LMNAMAPTGAA | |
| SCHEMBL9396517 | 0.75 | BCHE (0.54) | KMT2AMEN1LMNATSHRCYP1A2 | |
| SCHEMBL28513971 | 0.75 | ALDH1A1 (0.52) | KMT2AMEN1LMNAGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904266-A4 | NITROSATED AND NITROSYLATED COMPOUNDS AND COMPOSITIONS AND THEIR USE FOR TREATING RESPIRATORY DISORDERS | NITROMED INC (US) | 2001-09-19 | — | — | EP | disclosed |
| EP-0904266-A1 | NITROSATED AND NITROSYLATED COMPOUNDS AND COMPOSITIONS AND THEIR USE FOR TREATING RESPIRATORY DISORDERS | Nitromed, Inc. (US) | 1999-03-31 | — | — | EP | disclosed |
| WO-1997034871-A1 | NITROSATED AND NITROSYLATED COMPOUNDS AND COMPOSITIONS AND THEIR USE FOR TREATING RESPIRATORY DISORDERS | NITROMED, INC. (US) | 1997-09-25 | — | — | WO | disclosed |