Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 9/20 | 0.47 |
| ▸ | HRH2 | P25021 | 8/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839579 | 0.92 | HRH3 (0.48) | HRH3MAOBHRH1HRH2KDM1A | |
| SCHEMBL7828732 | 0.90 | HRH3 (0.47) | HRH3MAOBHRH1HRH2KDM1A | |
| SCHEMBL7839230 | 0.90 | KCNH2 (0.49) | HRH3MAOBHRH1HRH2KCNH2 | |
| SCHEMBL7846152 | 0.88 | LTA4H (0.55) | HRH3MAOBHRH1HRH2KDM1A | |
| SCHEMBL7839234 | 0.85 | LTA4H (0.54) | HRH3HRH1KDM1ALTA4H | |
| SCHEMBL9398887 | 0.84 | HRH2 (0.47) | HRH3MAOBHRH1HRH2KCNH2 | |
| SCHEMBL7840842 | 0.83 | HRH3 (0.47) | HRH3MAOBHRH1HRH2KCNH2 | |
| SCHEMBL7838309 | 0.82 | NPC1 (0.44) | HRH1KCNH2 | |
| SCHEMBL7836502 | 0.81 | HRH3 (0.47) | HRH3MAOBHRH1HRH2KCNH2 | |
| SCHEMBL9084007 | 0.80 | LTA4H (0.53) | HRH3MAOBHRH1HRH2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626968-B1 | PIPERIDINYL THIACYCLIC DERIVATIVES | MERRELL PHARMA INC (US) | 2001-09-26 | — | — | EP | disclosed |
| US-5650416-A | Piperidinyl thiacyclic derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-07-22 | — | — | US | disclosed |
| US-5631268-A | ANTIALLERGENS, 5HT2 RECEPTOR ANTAGONISTS | MERRELL PHARMACEUTICALS INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-5602147-A | Piperidinyl thiacyclic derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-02-11 | — | — | US | disclosed |
| US-5596003-A | Piperidinyl thiacyclic derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5541200-A | Piperidinyl thiacyclic derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5476861-A | Piperidinyl thiacyclic derivatives | MERRELL DOW PHARMACEURICALS INC. (US) | 1995-12-19 | — | — | US | disclosed |
| US-5371093-A | Piperidinyl thiacyclic derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-12-06 | — | — | US | disclosed |
| WO-1993016081-A1 | PIPERIDINYL THIACYCLIC DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-19 | — | — | WO | disclosed |