Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846152 | 0.90 | LTA4H (0.55) | LTA4HHRH3HTR1ADRD2HTR2A | |
| SCHEMBL9398887 | 0.90 | HRH2 (0.47) | MAPTNPC1RAB9AHRH3DRD2 | |
| SCHEMBL7839234 | 0.86 | LTA4H (0.54) | LTA4HHRH3HTR1ADRD2HTR2A | |
| SCHEMBL7839579 | 0.81 | HRH3 (0.48) | MAPTHRH3DRD2MAOBHRH1 | |
| SCHEMBL7840871 | 0.80 | HRH3 (0.48) | LTA4HHRH3MAOBHRH1HRH2 | |
| SCHEMBL7836502 | 0.79 | HRH3 (0.47) | HRH3MAOBHRH1KMT2AHRH2 | |
| SCHEMBL7828710 | 0.79 | LTA4H (0.62) | LTA4HMAPTNPC1RAB9AHTR1A | |
| SCHEMBL7828732 | 0.78 | HRH3 (0.47) | HRH3MAOBHRH1HRH2 | |
| SCHEMBL7840842 | 0.78 | HRH3 (0.47) | HRH3MAOBHRH1ALDH1A1HRH2 | |
| SCHEMBL7839230 | 0.78 | KCNH2 (0.49) | HRH3DRD2MAOBHRH1HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541200-A | Piperidinyl thiacyclic derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-30 | — | — | US | disclosed |