Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.51 |
| ▸ | TYR | P14679 | 1/20 | 0.51 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7682529 | 0.88 | ALDH1A1 (0.61) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL8121860 | 0.88 | KDM4E (0.67) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL177349 | 0.87 | ALDH1A1 (0.58) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL29707984 | 0.87 | ALDH1A1 (0.63) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL7840891 | 0.87 | ALDH1A1 (0.63) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL15331330 | 0.86 | ALDH1A1 (0.58) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL2558788 | 0.85 | ALDH1A1 (0.61) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL27299068 | 0.84 | MAPT (0.56) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL29957035 | 0.83 | ALDH1A1 (0.60) | ALDH1A1MAPTKDM4ERAB9ATRIM24 | |
| SCHEMBL29951784 | 0.82 | POLB (0.60) | ALDH1A1MAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882030-B1 | 2,1,3-BENZOTHIA(OXA)DIAZOLE DERIVATIVES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT | MERCK PATENT GMBH (DE) | 2001-09-12 | — | — | EP | disclosed |
| EP-0733631-B1 | Benzofuran derivates useful as hypoglycemic and hypolidemic agents | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-07-12 | — | — | EP | disclosed |
| US-6017939-A | 2,1,3-benzothia(OXA)diazole derivatives having an endothelin receptor antagonistic effect | MERCK PATENT GESELLSCHAFT (DE) | 2000-01-25 | — | — | US | disclosed |
| EP-0882030-A1 | 2,1,3-BENZOTHIA(OXA)DIAZOLE DERIVATIVES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT | MERCK PATENT GmbH (DE) | 1998-12-09 | — | — | EP | disclosed |
| WO-1998042702-A1 | ENDOTHELIN-RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 1998-10-01 | — | — | WO | disclosed |
| US-5723479-A | ANTILIPEMIC AGENTS AND ANTIGLYCEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-03 | — | — | US | disclosed |
| WO-1997030982-A1 | 2,1,3-BENZOTHIA(OXA)DIAZOLE DERIVATIVES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-08-28 | — | — | WO | disclosed |
| EP-0733631-A1 | Benzofuran derivates useful as hypoglycemic and hypolidemic agents | Takeda Chemical Industries, Ltd. (JP) | 1996-09-25 | — | — | EP | disclosed |