Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 4/20 | 0.75 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.65 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840931 | 1.00 | AKR1C1 (0.75) | AKR1C1AKR1C3AKR1C2PTGS2KMT2A | |
| SCHEMBL39275 | 0.86 | AKR1C1 (1.00) | AKR1C1AKR1C3AKR1C2PTGS2KMT2A | |
| SCHEMBL181529 | 0.86 | AKR1C1 (1.00) | AKR1C1AKR1C3AKR1C2PTGS2KMT2A | |
| SCHEMBL290469 | 0.86 | AKR1C1 (1.00) | AKR1C1AKR1C3AKR1C2PTGS2KMT2A | |
| SCHEMBL6513319 | 0.86 | AKR1C1 (0.55) | AKR1C1AKR1C3AKR1C2PTGS2KMT2A | |
| SCHEMBL6513317 | 0.86 | AKR1C1 (0.55) | AKR1C1AKR1C3AKR1C2PTGS2KMT2A | |
| SCHEMBL27448137 | 0.84 | AKR1C1 (0.96) | AKR1C1AKR1C3AKR1C2PTGS2KMT2A | |
| SCHEMBL4463208 | 0.83 | AKR1C1 (0.78) | AKR1C1AKR1C3AKR1C2PTGS2KMT2A | |
| SCHEMBL6384205 | 0.83 | AKR1C1 (0.78) | AKR1C1AKR1C3AKR1C2PTGS2KMT2A | |
| SCHEMBL13092046 | 0.83 | AKR1C1 (0.78) | AKR1C1AKR1C3AKR1C2PTGS2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |