Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.66 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.63 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8003190 | 0.85 | OPRM1 (0.49) | OPRM1OPRD1OPRL1 | |
| SCHEMBL7664626 | 0.84 | OPRM1 (0.66) | OPRM1OPRD1OPRL1ADRA1DADRA1A | |
| SCHEMBL11602782 | 0.84 | OPRM1 (0.66) | OPRM1OPRD1OPRL1ADRA1DADRA1A | |
| SCHEMBL10795357 | 0.84 | OPRM1 (0.66) | OPRM1OPRD1OPRL1ADRA1DADRA1A | |
| SCHEMBL11602963 | 0.84 | OPRM1 (0.70) | OPRM1OPRD1OPRL1ADRA1DADRA1A | |
| SCHEMBL8970808 | 0.83 | OPRM1 (0.82) | OPRM1OPRD1OPRL1ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL11602803 | 0.83 | OPRM1 (0.68) | OPRM1OPRD1OPRL1ADRA1DADRA1A | |
| SCHEMBL27796310 | 0.82 | OPRM1 (0.71) | OPRM1OPRD1OPRL1ADRA1DADRA1A | |
| SCHEMBL6198369 | 0.82 | OPRM1 (0.71) | OPRM1OPRD1OPRL1ADRA1DADRA1A | |
| SCHEMBL6891511 | 0.81 | OPRM1 (0.69) | OPRM1OPRD1OPRL1ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140876-A1 | MORPHOLINONE AND MORPHOLINE DERIVATIVES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035891-A1 | MORPHOLINONE AND MORPHOLINE DERIVATIVES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |