Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.58 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL476404 | 0.84 | OPRM1 (1.00) | OPRM1OPRD1OPRL1SIGMAR1 | |
| SCHEMBL7664626 | 0.83 | OPRM1 (0.66) | OPRM1OPRD1OPRL1ADRA1DADRA1A | |
| SCHEMBL11602782 | 0.83 | OPRM1 (0.66) | OPRM1OPRD1OPRL1ADRA1DADRA1A | |
| SCHEMBL10795357 | 0.83 | OPRM1 (0.66) | OPRM1OPRD1OPRL1ADRA1DADRA1A | |
| SCHEMBL11602963 | 0.83 | OPRM1 (0.70) | OPRM1OPRD1OPRL1ADRA1DADRA1A | |
| SCHEMBL7840973 | 0.83 | OPRM1 (0.66) | OPRM1OPRD1OPRL1ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL2473959 | 0.83 | OPRM1 (0.97) | OPRM1OPRD1OPRL1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL11602803 | 0.82 | OPRM1 (0.68) | OPRM1OPRD1OPRL1ADRA1DADRA1A | |
| SCHEMBL6198369 | 0.81 | OPRM1 (0.71) | OPRM1OPRD1OPRL1ADRA1DADRA1A | |
| SCHEMBL27796310 | 0.81 | OPRM1 (0.71) | OPRM1OPRD1OPRL1ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5480892-A | SIGMA RECEPTOR ANTAGONISTS; TREATMENT OF PHYSIOLOGICAL OR DRUG INDUCED PSYCHOSIS AND DYSKINESIA | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-01-02 | — | — | US | disclosed |
| US-5356906-A | (N-phthalimidoalkyl) piperidines useful as treatments for psychosis | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| WO-1993022310-A1 | (N-PHTHALIMIDOALKYL)PIPERIDINES FOR THE TREATMENT OF PSYCHOSES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-11-11 | — | — | WO | disclosed |
| EP-0497843-A4 | (N-PHTHALIMIDOALKYL) PIPERIDINES | — | 1992-09-23 | — | — | EP | disclosed |
| EP-0497843-A1 | (N-PHTHALIMIDOALKYL) PIPERIDINES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-08-12 | — | — | EP | disclosed |
| WO-1991006297-A1 | (N-PHTHALIMIDOALKYL) PIPERIDINES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-05-16 | — | — | WO | disclosed |