Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 14/20 | 0.72 |
| ▸ | RARB | P10826 | 8/20 | 0.72 |
| ▸ | RARG | P13631 | 6/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 7/20 | 0.38 |
| ▸ | RXRB | P28702 | 5/20 | 0.38 |
| ▸ | RARA | P10276 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840977 | 1.00 | RXRA (0.72) | RXRARARBRARGKDM4EALDH1A1 | |
| SCHEMBL7840972 | 1.00 | RXRA (0.72) | RXRARARBRARGKDM4EALDH1A1 | |
| SCHEMBL4879231 | 0.86 | RXRA (0.96) | RXRARARBRARGRXRGRXRB | |
| SCHEMBL4879243 | 0.86 | RXRA (0.96) | RXRARARBRARGRXRGRXRB | |
| SCHEMBL8359441 | 0.85 | RXRA (0.94) | RXRARARBRARGRXRGRXRB | |
| SCHEMBL8359437 | 0.85 | RXRA (0.94) | RXRARARBRARGRXRGRXRB | |
| SCHEMBL8674942 | 0.85 | RXRA (0.94) | RXRARARBRARGRXRGRXRB | |
| SCHEMBL8197218 | 0.83 | RXRA (1.00) | RXRARARBRARGRXRGRXRB | |
| SCHEMBL8197354 | 0.83 | RXRA (1.00) | RXRARARBRARGRXRGRXRB | |
| SCHEMBL7843636 | 0.83 | RXRA (0.77) | RXRARARBRARGKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718285-B1 | Restricted 9-cis-retinoids | AMERICAN CYANAMID CO (US) | 2001-04-11 | — | — | EP | disclosed |
| EP-0997455-A1 | Restricted 9-cis retenoids | American Cyanamid Company (US) | 2000-05-03 | — | — | EP | disclosed |
| US-5968908-A | Restricted 9-cis retinoids | AMERICAN CYANAMID COMPANY (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0718285-A2 | Restricted 9-cis-retinoids | American Cyanamid Company (US) | 1996-06-26 | — | — | EP | disclosed |