Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 13/20 | 0.77 |
| ▸ | RARB | P10826 | 9/20 | 0.53 |
| ▸ | RARG | P13631 | 7/20 | 0.53 |
| ▸ | RXRB | P28702 | 8/20 | 0.42 |
| ▸ | RXRG | P48443 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8197246 | 1.00 | RXRA (0.77) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL8197234 | 0.89 | RXRA (0.96) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL8197238 | 0.89 | RXRA (0.96) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7841661 | 0.87 | RXRA (1.00) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7841660 | 0.87 | RXRA (1.00) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7840972 | 0.83 | RXRA (0.72) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7840978 | 0.83 | RXRA (0.72) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7840977 | 0.83 | RXRA (0.72) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL8189608 | 0.76 | RXRA (0.73) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL8198158 | 0.75 | RXRA (0.72) | RXRARARBRARGRXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718285-B1 | Restricted 9-cis-retinoids | AMERICAN CYANAMID CO (US) | 2001-04-11 | — | — | EP | disclosed |
| EP-0997455-A1 | Restricted 9-cis retenoids | American Cyanamid Company (US) | 2000-05-03 | — | — | EP | disclosed |
| US-5968908-A | Restricted 9-cis retinoids | AMERICAN CYANAMID COMPANY (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0718285-A2 | Restricted 9-cis-retinoids | American Cyanamid Company (US) | 1996-06-26 | — | — | EP | disclosed |