SCHEMBL7841138

SCHEMBL7841138

O=C(O)c1cn(-c2ccc(F)cc2)c2nc(Cl)ccc2c1=O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.49
KDM4E B2RXH2 2/20 0.49
KMT2A Q03164 3/20 0.44
MEN1 O00255 2/20 0.44
ALDH1A1 P00352 1/20 0.43
HPGD P15428 1/20 0.43
HSD17B10 Q99714 1/20 0.43
CAPN1 P07384 1/20 0.43
EPHA2 P29317 1/20 0.41
FLT4 P35916 1/20 0.41
GSK3B P49841 1/20 0.41
RARB P10826 1/20 0.41
TBXAS1 P24557 1/20 0.41
SLC6A3 Q01959 1/20 0.41
ENPP2 Q13822 1/20 0.41
ABCC4 O15439 1/20 0.41
PKM P14618 1/20 0.41
PTGS1 P23219 1/20 0.41
PIM1 P11309 3/20 0.40
KCNH2 Q12809 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9149681 0.84 EPHA2 (0.57) LMNAKDM4EKMT2AMEN1ALDH1A1
SCHEMBL27274437 0.83 LMNA (0.47) LMNAKDM4EKMT2AMEN1ALDH1A1
SCHEMBL6211205 0.83 LMNA (0.50) LMNAKDM4EKMT2AMEN1ALDH1A1
SCHEMBL18306002 0.83 EPHA2 (0.40) LMNAKDM4EKMT2AMEN1ALDH1A1
SCHEMBL18306037 0.83 EPHA2 (0.44) LMNAKDM4EKMT2AMEN1ALDH1A1
SCHEMBL7012684 0.81 EPHA2 (0.42) LMNAKDM4EKMT2AMEN1ALDH1A1
SCHEMBL18305936 0.81 CHRM1 (0.41) LMNAKDM4EKMT2AMEN1ALDH1A1
SCHEMBL19784161 0.81 KMT2A (0.39) LMNAKDM4EKMT2AMEN1ALDH1A1
SCHEMBL11051594 0.81 ALDH1A1 (0.46) LMNAKDM4EKMT2AMEN1ALDH1A1
SCHEMBL18305969 0.80 EPHA2 (0.42) LMNAKDM4EKMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0677050-B1 NOVEL PYRIDONE CARBOXYLIC ACID DERIVATIVES CHEIL JEDANG CORP (KR) 2001-08-16 EP disclosed
CN-1042632-C Novel pyridone carboxylic acid derivatives NO 1 SUGAR REFINING CO LTD (KR) 1999-03-24 CN disclosed
US-5688965-A BACTERICIDES CHEIL FOODS & CHEMICALS, INC. (KR) 1997-11-18 US disclosed
US-5527910-A BACTERICIDES; STAPHYLOCOCCUS, STREPTOCOCCUS INFECTIONS CHEIL FOODS & CHEMICALS, INC. (KR) 1996-06-18 US disclosed