Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | FOLR1 | P15328 | 4/20 | 0.33 |
| ▸ | SLC19A1 | P41440 | 4/20 | 0.33 |
| ▸ | SLC46A1 | Q96NT5 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TYMS | P04818 | 4/20 | 0.32 |
| ▸ | GART | P22102 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852327 | 0.82 | FOLR1 (0.55) | FOLR1SLC19A1SLC46A1TYMSGART | |
| SCHEMBL7843073 | 0.81 | FOLR1 (0.51) | FOLR1SLC19A1SLC46A1TYMSGART | |
| SCHEMBL7851441 | 0.80 | MMP12 (0.37) | — | |
| SCHEMBL7851872 | 0.78 | TYMS (0.43) | TYMSGAA | |
| SCHEMBL7851328 | 0.73 | DAO (0.33) | DAOFOLR1SLC19A1SLC46A1LMNA | |
| SCHEMBL7858260 | 0.70 | NPSR1 (0.42) | FOLR1SLC19A1SLC46A1LMNATYMS | |
| SCHEMBL7853357 | 0.66 | TYMS (0.51) | FOLR1SLC19A1SLC46A1TYMSGART | |
| SCHEMBL2141423 | 0.62 | DAO (0.64) | DAOALDH1A1GAA | |
| SCHEMBL7854494 | 0.62 | TYMS (0.43) | TYMSGAA | |
| SCHEMBL7851196 | 0.62 | TYMS (0.48) | L3MBTL1TYMSALDH1A1MAPK1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923287-A4 | NONCLASSICAL PYRROLO 2,3-D]PYRIMIDINE ANTIFOLATES | LILLY CO ELI (US) | 2001-08-01 | — | — | EP | disclosed |
| EP-0923287-A1 | NONCLASSICAL PYRROLO 2,3-D]PYRIMIDINE ANTIFOLATES | ELI LILLY AND COMPANY (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008382-A1 | NONCLASSICAL PYRROLO[2,3-D]PYRIMIDINE ANTIFOLATES | ELI LILLY AND COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |