Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.34 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843083 | 0.86 | ALDH1A1 (0.41) | MAPTALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL7829126 | 0.81 | KDM4E (0.41) | MAPTTP53TACR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6946876 | 0.80 | TTR (0.35) | TP53SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL6153461 | 0.80 | CYP4F2 (0.34) | TP53SMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL6949307 | 0.80 | CYP2C9 (0.32) | MAPTTP53SMN1; SMN2CYP2D6ALDH1A1 | |
| SCHEMBL7836265 | 0.79 | SLC7A5 (0.39) | ALDH1A1KDM4EMEN1KMT2ASLC7A5 | |
| SCHEMBL6153189 | 0.79 | CYP2C9 (0.32) | TP53SMN1; SMN2CYP2D6ALDH1A1KDM4E | |
| SCHEMBL6152821 | 0.77 | KMT2A (0.31) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6948274 | 0.76 | SMN1; SMN2 (0.42) | MAPTTP53KCNH2SMN1; SMN2CYP2D6 | |
| SCHEMBL6153144 | 0.76 | PPARG (0.35) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777653-B1 | DIHYGROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS | PFIZER (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5859011-A | Dihydropyridine derivatives as bradykinin antagonist | PFIZER INC. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1996006082-A1 | DIHYDROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS | PFIZER INC. (US) | 1996-02-29 | — | — | WO | disclosed |