Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949307 | 0.89 | CYP2C9 (0.32) | ALDH1A1NPC1RAB9AKDM4EGAA | |
| SCHEMBL6946876 | 0.89 | TTR (0.35) | ALDH1A1NPC1RAB9AUSP2MEN1 | |
| SCHEMBL6153461 | 0.89 | CYP4F2 (0.34) | ALDH1A1NPC1RAB9AKDM4EUSP2 | |
| SCHEMBL6153189 | 0.88 | CYP2C9 (0.32) | ALDH1A1NPC1RAB9AKDM4EUSP2 | |
| SCHEMBL6153097 | 0.87 | ALDH1A1 (0.31) | ALDH1A1NR3C2HPGDHTT | |
| SCHEMBL7836265 | 0.86 | SLC7A5 (0.39) | ALDH1A1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL6152821 | 0.86 | KMT2A (0.31) | ALDH1A1KDM4EUSP2MEN1KMT2A | |
| SCHEMBL6940682 | 0.86 | PPARD (0.35) | ALDH1A1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL7841344 | 0.86 | MAPT (0.35) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL6153144 | 0.85 | PPARG (0.35) | ALDH1A1MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777653-B1 | DIHYGROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS | PFIZER (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5859011-A | Dihydropyridine derivatives as bradykinin antagonist | PFIZER INC. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1996006082-A1 | DIHYDROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS | PFIZER INC. (US) | 1996-02-29 | — | — | WO | disclosed |