SCHEMBL7841398

SCHEMBL7841398

COc1ccc2nc(S(=O)(=O)NCc3ncc(C)c(OC)c3C)n(S(=O)(=O)c3ccc(OCC(N)=O)cc3)c2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.41
ALDH1A1 P00352 4/20 0.38
KMT2A Q03164 3/20 0.38
HTT P42858 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
WDR5 P61964 2/20 0.38
BRS3 P32247 2/20 0.38
ATP1A1 P05023 2/20 0.38
ATP1B1 P05026 2/20 0.38
ATP1A3 P13637 2/20 0.38
ATP1B2 P14415 2/20 0.38
ATP4A P20648 2/20 0.38
ATP1A2 P50993 2/20 0.38
ATP4B P51164 2/20 0.38
ATP1B3 P54709 2/20 0.38
FXYD2 P54710 2/20 0.38
ATP1A4 Q13733 2/20 0.38
KDM4E B2RXH2 1/20 0.38
DDAH1 O94760 1/20 0.38
ABCB11 O95342 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7856584 0.88 CYP2C9 (0.44) CYP2C9ALDH1A1KMT2AHTTSMN1; SMN2
SCHEMBL7854524 0.87 CYP2C9 (0.37) CYP2C9ALDH1A1KMT2AHTTSMN1; SMN2
SCHEMBL7857124 0.86 KDM4E (0.42) CYP2C9ALDH1A1KMT2AKDM4EMAPT
SCHEMBL7841625 0.85 CYP2C9 (0.40) CYP2C9ALDH1A1KMT2AHTTSMN1; SMN2
SCHEMBL5365325 0.83 BRS3 (0.48) CYP2C9ALDH1A1KMT2AHTTSMN1; SMN2
SCHEMBL7854118 0.83 CYP2C9 (0.43) CYP2C9ALDH1A1KMT2AHTTSMN1; SMN2
SCHEMBL7008064 0.82 CYP2C9 (0.42) CYP2C9ALDH1A1KMT2AHTTSMN1; SMN2
SCHEMBL14387816 0.80 CYP2C9 (0.39) CYP2C9ALDH1A1KMT2AHTTSMN1; SMN2
SCHEMBL6478121 0.80 CYP2C9 (0.51) CYP2C9ALDH1A1KMT2AHTTSMN1; SMN2
SCHEMBL4796458 0.80 CYP2C9 (0.36) CYP2C9ALDH1A1KMT2AHTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1105387-A1 PRODRUGS OF PROTON PUMP INHIBITORS Partnership of Michael E. Garst, George Sachs and Jai Moo Shin (US) 2001-06-13 EP claimed
WO-2000009498-A1 PRODRUGS OF PROTON PUMP INHIBITORS PARTNERSHIP OF MICHAEL E. GARST, GEORGE SACHS AND JAI MOO SHIN (US) 2000-02-24 WO claimed