Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.37 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841398 | 0.86 | CYP2C9 (0.41) | KDM4EKMT2ALMNAMEN1MAPT | |
| SCHEMBL7006314 | 0.85 | KDM4E (0.41) | KDM4ERXFP1KMT2ALMNAMEN1 | |
| SCHEMBL7831809 | 0.83 | KDM4E (0.39) | KDM4ERXFP1KMT2ALMNAMEN1 | |
| SCHEMBL7856584 | 0.82 | CYP2C9 (0.44) | KDM4EKMT2ALMNAMEN1MAPT | |
| SCHEMBL7854524 | 0.80 | CYP2C9 (0.37) | KDM4EKMT2ALMNAMEN1MAPT | |
| SCHEMBL7007593 | 0.80 | KDM4E (0.41) | KDM4ERXFP1KMT2ALMNAMEN1 | |
| SCHEMBL7841625 | 0.78 | CYP2C9 (0.40) | KDM4EKMT2ALMNAMEN1MAPT | |
| SCHEMBL7854118 | 0.78 | CYP2C9 (0.43) | KDM4EKMT2ALMNAMEN1MAPT | |
| SCHEMBL6478121 | 0.75 | CYP2C9 (0.51) | KDM4EKMT2ALMNAMEN1MAPT | |
| SCHEMBL4796458 | 0.75 | CYP2C9 (0.36) | KDM4EKMT2ALMNAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105387-A1 | PRODRUGS OF PROTON PUMP INHIBITORS | Partnership of Michael E. Garst, George Sachs and Jai Moo Shin (US) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000009498-A1 | PRODRUGS OF PROTON PUMP INHIBITORS | PARTNERSHIP OF MICHAEL E. GARST, GEORGE SACHS AND JAI MOO SHIN (US) | 2000-02-24 | — | — | WO | disclosed |