Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.62 |
| ▸ | HTR2C | P28335 | 7/20 | 0.62 |
| ▸ | HTR2B | P41595 | 7/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALPG | P10696 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843799 | 0.87 | HTR2A (0.46) | HTR2AHTR2CHTR2BEPHX2MEN1 | |
| Ammonia Solution, Strong SCHEMBL906075 | 0.82 | HTR2A (0.62) | HTR2AHTR2CHTR2BHDAC1HDAC6 | |
| SCHEMBL14473195 | 0.80 | HTR2A (0.67) | HTR2AHTR2CHTR2BHDAC1HDAC6 | |
| SCHEMBL21008386 | 0.77 | HTR2A (0.56) | HTR2AHTR2CHTR2BHDAC1HDAC6 | |
| SCHEMBL7833793 | 0.77 | EPHX2 (0.46) | HTR2AHDAC1HDAC6EPHX2MEN1 | |
| SCHEMBL906072 | 0.77 | HTR2A (1.00) | HTR2AHTR2CHTR2BHDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL7845930 | 0.76 | HTR2A (0.57) | HTR2AHTR2CHTR2BHDAC1HDAC6 | |
| SCHEMBL2625795 | 0.74 | HTR2A (0.55) | HTR2AHTR2CHTR2BHDAC1HDAC6 | |
| SCHEMBL7840357 | 0.71 | ALDH1A1 (0.42) | HTR2AHTR2CHTR2BHDAC1HDAC6 | |
| SCHEMBL7674589 | 0.71 | HTR2A (0.58) | HTR2AHTR2CHTR2BHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109784-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2001-06-27 | — | — | EP | claimed |
| WO-2000012475-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | claimed |
| EP-1109784-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012475-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |