Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | FPR3 | P25089 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17141297 | 0.86 | MTNR1A (0.51) | MTNR1AMTNR1BBCHENQO2KDM4E | |
| SCHEMBL26837472 | 0.85 | MTNR1A (0.72) | MTNR1AMTNR1BBCHENQO2KDM4E | |
| SCHEMBL29736233 | 0.85 | MTNR1A (0.72) | MTNR1AMTNR1BBCHENQO2KDM4E | |
| SCHEMBL20287498 | 0.82 | ALOX15 (0.49) | BCHE | |
| SCHEMBL17140836 | 0.82 | MTNR1A (0.47) | MTNR1AMTNR1BBCHENQO2ALDH1A1 | |
| SCHEMBL20289680 | 0.81 | ALOX15 (0.51) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL19964551 | 0.78 | SMN1; SMN2 (0.55) | MTNR1AMTNR1BBCHEAAK1SMN1; SMN2 | |
| SCHEMBL23037699 | 0.78 | BCHE (0.41) | MTNR1AMTNR1BBCHENQO2AAK1 | |
| SCHEMBL31359957 | 0.77 | BCHE (0.42) | MTNR1AMTNR1BBCHENQO2KDM4E | |
| SCHEMBL23037651 | 0.76 | NQO2 (0.40) | MTNR1AMTNR1BBCHENQO2AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109784-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012475-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |