Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7850907 | 0.99 | ALDH1A1 (0.35) | ALDH1A1POLBCHRM2CHRM1OPRM1 | |
| Hydrochloric Acid SCHEMBL7848827 | 0.98 | ALDH1A1 (0.35) | ALDH1A1POLBCHRM2CHRM1OPRM1 | |
| SCHEMBL7848963 | 0.90 | ALDH1A1 (0.32) | ALDH1A1POLBCHRM2CHRM1OPRM1 | |
| SCHEMBL7841774 | 0.89 | TOP2A (0.33) | ALDH1A1POLBCHRM2CHRM1OPRM1 | |
| Bromide SCHEMBL8692350 | 0.89 | POLB (0.45) | ALDH1A1POLBCHRM2CHRM1OPRM1 | |
| SCHEMBL7851222 | 0.89 | CYP3A4 (0.31) | — | |
| SCHEMBL7849623 | 0.89 | ALDH1A1 (0.35) | ALDH1A1POLBCHRM2CHRM1OPRM1 | |
| SCHEMBL7850903 | 0.88 | POLB (0.46) | ALDH1A1POLBCHRM2CHRM1OPRM1 | |
| SCHEMBL7849867 | 0.88 | ALDH1A1 (0.31) | ALDH1A1POLBCHRM2CHRM1OPRM1 | |
| Hydrochloric Acid SCHEMBL8697994 | 0.87 | POLB (0.45) | ALDH1A1POLBCHRM2CHRM1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726270-B1 | Derivatives of 1,6-naphthyridone carboxylic acids | BAYER AG (DE) | 2001-05-23 | — | — | EP | disclosed |
| EP-0726270-A1 | Derivatives of 1,6-naphthyridine carboxylic acids | BAYER AG (DE) | 1996-08-14 | — | — | EP | disclosed |