Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 7/20 | 0.44 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.43 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7850903 | 0.90 | POLB (0.46) | TOP2ATOP2BMEN1KMT2AKCNH2 | |
| SCHEMBL7841774 | 0.89 | TOP2A (0.33) | TOP2ATOP2BMEN1KMT2AKCNH2 | |
| Hydrochloric Acid SCHEMBL8697994 | 0.89 | POLB (0.45) | TOP2ATOP2BMEN1KMT2AKCNH2 | |
| Bromide SCHEMBL8692350 | 0.89 | POLB (0.45) | TOP2ATOP2BMEN1KMT2AKCNH2 | |
| SCHEMBL7853917 | 0.85 | TOP2A (0.42) | TOP2ATOP2BMEN1KMT2AKCNH2 | |
| SCHEMBL9145431 | 0.84 | KCNH2 (0.47) | TOP2ATOP2BMEN1KMT2AKCNH2 | |
| SCHEMBL8133384 | 0.84 | ALDH1A1 (0.56) | TOP2ATOP2BMEN1KMT2AKCNH2 | |
| Hydrochloric Acid SCHEMBL9149906 | 0.83 | KCNH2 (0.47) | TOP2ATOP2BMEN1KMT2AKCNH2 | |
| SCHEMBL7841768 | 0.81 | EPHA2 (0.56) | TOP2ATOP2BMEN1KMT2APOLB | |
| SCHEMBL7851044 | 0.81 | KDM4E (0.42) | TOP2ATOP2BKCNH2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726270-B1 | Derivatives of 1,6-naphthyridone carboxylic acids | BAYER AG (DE) | 2001-05-23 | — | — | EP | disclosed |
| US-5811433-A | ANTIMICROBIALS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-09-22 | — | — | US | disclosed |
| EP-0726270-A1 | Derivatives of 1,6-naphthyridine carboxylic acids | BAYER AG (DE) | 1996-08-14 | — | — | EP | disclosed |