Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.43 |
| ▸ | GCGR | P47871 | 4/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | MATK | P42679 | 1/20 | 0.42 |
| ▸ | FRK | P42685 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839793 | 0.84 | PTGS2 (0.67) | PTGS2PTGS1MAPK14MAPK13GCGR | |
| SCHEMBL7843097 | 0.84 | PTGS2 (0.67) | PTGS2PTGS1MAPK14MAPK13GCGR | |
| SCHEMBL7847052 | 0.83 | PTGDR2 (0.51) | PTGS2PTGS1MAPK14 | |
| SCHEMBL7833914 | 0.83 | PTGS2 (0.68) | PTGS2PTGS1MAPK14MAPK13GCGR | |
| SCHEMBL2516749 | 0.83 | PTGS2 (0.67) | PTGS2PTGS1MAPK14 | |
| SCHEMBL7844360 | 0.81 | PTGS2 (0.69) | PTGS2PTGS1MAPK14MAPK13GCGR | |
| SCHEMBL7844983 | 0.81 | PTGS2 (0.62) | PTGS2PTGS1MAPK14MAPK13GCGR | |
| SCHEMBL7833390 | 0.81 | PTGS2 (0.62) | PTGS2PTGS1MAPK14MAPK13GCGR | |
| SCHEMBL7842822 | 0.80 | PPARD (0.55) | PTGS2PTGS1 | |
| SCHEMBL2793703 | 0.80 | PTGS2 (0.67) | PTGS2PTGS1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |