Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 18/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852850 | 0.91 | PTGS2 (0.56) | PPARDPTGS2PTGS1 | |
| SCHEMBL7845630 | 0.86 | PTGS2 (0.68) | PPARDPTGS2PTGS1 | |
| SCHEMBL7840151 | 0.83 | PTGS1 (0.57) | PPARDPTGS2PTGS1 | |
| SCHEMBL7840968 | 0.82 | PTGS2 (0.71) | PPARDPTGS2PTGS1 | |
| SCHEMBL7843982 | 0.81 | PTGS2 (0.48) | PPARDPTGS2PTGS1 | |
| SCHEMBL7841792 | 0.80 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL7842827 | 0.78 | PPARD (0.49) | PPARDPTGS2PTGS1 | |
| SCHEMBL7841299 | 0.78 | PTGS2 (0.72) | PTGS2PTGS1 | |
| SCHEMBL7843553 | 0.78 | PTGS2 (0.72) | PTGS2PTGS1 | |
| SCHEMBL14436048 | 0.77 | PPARD (0.88) | PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |