Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842346 | 0.93 | PTGS2 (0.55) | PTGS2PTGS1MAPK14GAAMAPT | |
| SCHEMBL7844299 | 0.91 | PTGS2 (0.53) | PTGS2PTGS1MAPK14GAAMAPT | |
| SCHEMBL7842708 | 0.91 | PTGS2 (0.62) | PTGS2PTGS1MAPK14PIK3CDPIK3CA | |
| SCHEMBL213895 | 0.88 | PTGS2 (0.65) | PTGS2PTGS1 | |
| SCHEMBL7846640 | 0.84 | PTGS2 (0.62) | PTGS2PTGS1MAPK14MAPTKDM4E | |
| SCHEMBL7846478 | 0.83 | PTGS2 (0.56) | PTGS2PTGS1MAPK14 | |
| SCHEMBL7845707 | 0.82 | PTGS2 (0.60) | PTGS2PTGS1MAPK14ALDH1A1PIK3CD | |
| SCHEMBL6282302 | 0.82 | MAPT (0.69) | PTGS2GAAMAPTKDM4EALDH1A1 | |
| SCHEMBL7833194 | 0.82 | PTGS2 (0.63) | PTGS2PTGS1 | |
| SCHEMBL6051420 | 0.80 | PTGS2 (0.60) | PTGS2PTGS1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |