Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.49 |
| ▸ | PRKX | P51817 | 1/20 | 0.49 |
| ▸ | NEK4 | P51957 | 1/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL216750 | 0.89 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL7842708 | 0.85 | PTGS2 (0.62) | PTGS2PTGS1MAPK14 | |
| SCHEMBL7841857 | 0.83 | PTGS2 (0.57) | PTGS2PTGS1MAPK14 | |
| SCHEMBL7842346 | 0.81 | PTGS2 (0.55) | PTGS2PTGS1MAPK14 | |
| SCHEMBL7846640 | 0.81 | PTGS2 (0.62) | PTGS2PTGS1MAPK14CSNK1D | |
| SCHEMBL7844433 | 0.80 | PTGS2 (0.80) | PTGS2MAPK14 | |
| SCHEMBL6280002 | 0.80 | ADORA3 (0.53) | PTGS2PTGS1MAPK14ROCK2GSK3B | |
| SCHEMBL7844299 | 0.80 | PTGS2 (0.53) | PTGS2PTGS1MAPK14 | |
| SCHEMBL7845707 | 0.79 | PTGS2 (0.60) | PTGS2PTGS1MAPK14CSNK1D | |
| SCHEMBL7841561 | 0.78 | PTGS2 (0.71) | PTGS2PTGS1ROCK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |