Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 8/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836868 | 0.84 | KDM1A (0.43) | KDM1AKDM4EALDH1A1RAD52KMT2A | |
| SCHEMBL7845566 | 0.81 | KDM1A (0.47) | KDM1AKDM4EALDH1A1RAD52KMT2A | |
| SCHEMBL6071828 | 0.81 | CYP19A1 (0.44) | CYP19A1KDM4EALDH1A1RAD52KMT2A | |
| SCHEMBL7842318 | 0.80 | MEN1 (0.47) | KDM1ACYP19A1KDM4EALDH1A1KMT2A | |
| SCHEMBL7999974 | 0.80 | KDM1A (0.43) | KDM1AKDM4EALDH1A1RAD52KMT2A | |
| SCHEMBL6071833 | 0.73 | CYP19A1 (0.46) | CYP19A1KDM4EALDH1A1RAD52KMT2A | |
| SCHEMBL7689595 | 0.70 | KDM1A (0.57) | KDM1AKDM4EALDH1A1RAD52KMT2A | |
| SCHEMBL7826829 | 0.69 | KDM1A (0.43) | KDM1AKDM4EALDH1A1RAD52KMT2A | |
| SCHEMBL4557943 | 0.68 | KDM1A (0.47) | KDM1AKDM4EALDH1A1RAD52KMT2A | |
| SCHEMBL28613370 | 0.67 | KDM1A (0.49) | KDM1AKDM4EALDH1A1RAD52KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | American Cyanamid Company (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018761-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-04-06 | — | — | WO | disclosed |