Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836872 | 0.84 | MEN1 (0.45) | MEN1KMT2ANPSR1RXFP1ALDH1A1 | |
| SCHEMBL6071833 | 0.82 | CYP19A1 (0.46) | MEN1KMT2ANPSR1RXFP1CYP19A1 | |
| SCHEMBL7845574 | 0.81 | MEN1 (0.48) | MEN1KMT2ANPSR1RXFP1ALDH1A1 | |
| SCHEMBL7842311 | 0.80 | KDM1A (0.46) | MEN1KMT2ANPSR1CYP19A1ALDH1A1 | |
| SCHEMBL7999981 | 0.80 | MEN1 (0.45) | MEN1KMT2ANPSR1RXFP1ALDH1A1 | |
| SCHEMBL7999933 | 0.75 | MEN1 (0.51) | MEN1KMT2ANPSR1RXFP1ALDH1A1 | |
| SCHEMBL6071828 | 0.72 | CYP19A1 (0.44) | KMT2ANPSR1RXFP1CYP19A1ALDH1A1 | |
| SCHEMBL20259096 | 0.70 | ALDH1A1 (0.58) | MEN1KMT2ANPSR1RXFP1ALDH1A1 | |
| SCHEMBL7689600 | 0.70 | ALDH1A1 (0.51) | MEN1KMT2ANPSR1RXFP1ALDH1A1 | |
| SCHEMBL7826836 | 0.69 | MEN1 (0.45) | MEN1KMT2ANPSR1RXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | American Cyanamid Company (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018761-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-04-06 | — | — | WO | disclosed |