Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 3/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842941 | 0.90 | CYP1A2 (0.47) | MAPK8MAPTMAPK1TP53ALDH1A1 | |
| SCHEMBL7850334 | 0.71 | GNRHR (0.48) | MAPTTP53KMT2AEDNRB | |
| SCHEMBL9288539 | 0.69 | GNRHR (0.46) | MAPTTP53EDNRB | |
| SCHEMBL7841358 | 0.68 | GNRHR (0.46) | MAPTMAPK1TP53ALDH1A1MEN1 | |
| SCHEMBL7512664 | 0.68 | SLC10A2 (0.43) | MAPK8MAPTMAPK1TP53ALDH1A1 | |
| SCHEMBL7508121 | 0.68 | GAA (0.49) | MAPTNPC1ALDH1A1RAB9ANPSR1 | |
| SCHEMBL8134728 | 0.66 | USP2 (0.52) | MEN1KMT2APKMPTGDR2 | |
| SCHEMBL6532025 | 0.65 | CYP1A2 (0.57) | MAPTTP53ALDH1A1NPSR1MEN1 | |
| SCHEMBL10487911 | 0.65 | AKR1B1 (0.59) | MAPK8MAPTMAPK1TP53ALDH1A1 | |
| SCHEMBL4713285 | 0.63 | MAPK8 (1.00) | MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640606-B1 | Thienopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-11-07 | — | — | EP | disclosed |
| US-6140325-A | HAS ENDOTHELIN ANTAGONISTIC ACTION; FOR TREATING LIVER HYPOFUNCTION, ACUTE RENAL INSUFFICIENCY, CARDIAC INFARCTION OR LIVER INSUFFICIENCY, VASOCONSTRICTION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-10-31 | — | — | US | disclosed |
| EP-0640606-A1 | Thienopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-03-01 | — | — | EP | disclosed |