Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 10/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | EDNRB | P24530 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9288539 | 0.93 | GNRHR (0.46) | GNRHRADORA2BEDNRBMAPTTP53 | |
| SCHEMBL7851611 | 0.91 | GNRHR (0.49) | GNRHRADORA2BKMT2AEDNRBMAPT | |
| SCHEMBL7850919 | 0.89 | ADORA2B (0.41) | GNRHRADORA2BKMT2AEDNRBMAPT | |
| SCHEMBL7857100 | 0.84 | GNRHR (0.55) | GNRHRADORA2BKMT2AEDNRBMAPT | |
| SCHEMBL7849577 | 0.84 | EDNRB (0.46) | GNRHRADORA2BKMT2AEDNRBTP53 | |
| SCHEMBL7850957 | 0.83 | ADORA2B (0.43) | GNRHRADORA2BKMT2AEDNRBTP53 | |
| SCHEMBL9285437 | 0.82 | ADORA2B (0.41) | GNRHRADORA2BKMT2AEDNRBTP53 | |
| SCHEMBL7851987 | 0.81 | ADORA2B (0.40) | GNRHRADORA2BKMT2AEDNRBMAPT | |
| SCHEMBL7854155 | 0.81 | ADORA2B (0.42) | GNRHRADORA2BKMT2AEDNRBMAPT | |
| SCHEMBL7852076 | 0.80 | GNRHR (0.44) | GNRHRADORA2BKMT2ATP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640606-B1 | Thienopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-11-07 | — | — | EP | claimed |
| US-6140325-A | HAS ENDOTHELIN ANTAGONISTIC ACTION; FOR TREATING LIVER HYPOFUNCTION, ACUTE RENAL INSUFFICIENCY, CARDIAC INFARCTION OR LIVER INSUFFICIENCY, VASOCONSTRICTION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-10-31 | — | — | US | claimed |
| EP-0640606-A1 | Thienopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-03-01 | — | — | EP | claimed |
| EP-0640606-B1 | Thienopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-11-07 | — | — | EP | disclosed |
| US-6140325-A | HAS ENDOTHELIN ANTAGONISTIC ACTION; FOR TREATING LIVER HYPOFUNCTION, ACUTE RENAL INSUFFICIENCY, CARDIAC INFARCTION OR LIVER INSUFFICIENCY, VASOCONSTRICTION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-10-31 | — | — | US | disclosed |
| EP-0640606-A1 | Thienopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-03-01 | — | — | EP | disclosed |