Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2512261 | 0.82 | GABRR1 (0.43) | SMN1; SMN2GABRR1 | |
| SCHEMBL7676177 | 0.81 | HTT (0.44) | SMN1; SMN2USP2GABRR1 | |
| Hydrochloric Acid SCHEMBL1375897 | 0.81 | GABRR1 (0.42) | SMN1; SMN2GABRR1 | |
| SCHEMBL682587 | 0.79 | USP2 (0.49) | SMN1; SMN2USP2 | |
| SCHEMBL8212933 | 0.77 | KMT2A (0.48) | SMN1; SMN2 | |
| SCHEMBL6105714 | 0.74 | — | — | |
| Acetic Acid SCHEMBL15528121 | 0.73 | NOTUM (0.31) | SMN1; SMN2GABRR1 | |
| SCHEMBL3930088 | 0.73 | NPSR1 (0.42) | SMN1; SMN2 | |
| SCHEMBL7444234 | 0.73 | BAZ2B (0.32) | — | |
| SCHEMBL148931 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831824-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2001-05-02 | — | — | EP | disclosed |
| EP-0831824-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996039140-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-12-12 | — | — | WO | disclosed |