SCHEMBL7843486

SCHEMBL7843486

Nc1ncccc1OCCCCl

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 1/20 0.56
MAPK14 Q16539 1/20 0.56
RAB9A P51151 7/20 0.51
NPC1 O15118 6/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
HTT P42858 1/20 0.51
MAPT P10636 3/20 0.51
PDE5A O76074 1/20 0.46
PDE4A P27815 1/20 0.46
PDE4B Q07343 1/20 0.46
PDE4C Q08493 1/20 0.46
PDE4D Q08499 1/20 0.46
NOS3 P29474 1/20 0.41
NOS1 P29475 1/20 0.41
NOS2 P35228 1/20 0.41
CYP1A2 P05177 2/20 0.39
CYP2C9 P11712 2/20 0.39
CYP2C19 P33261 2/20 0.39
MET P08581 1/20 0.38
MEN1 O00255 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7844990 0.94 LTA4H (0.54) LTA4HMAPK14RAB9ANPC1SMN1; SMN2
SCHEMBL11084194 0.85 LTA4H (0.56) LTA4HMAPK14RAB9ANPC1SMN1; SMN2
SCHEMBL28163876 0.84 LTA4H (0.59) LTA4HMAPK14RAB9ANPC1SMN1; SMN2
SCHEMBL23850962 0.83 LTA4H (0.54) LTA4HMAPK14RAB9ANPC1SMN1; SMN2
SCHEMBL18970261 0.83 LTA4H (0.54) LTA4HMAPK14RAB9ANPC1SMN1; SMN2
SCHEMBL7222828 0.83 CYP1A2 (0.59) LTA4HMAPK14RAB9ANPC1SMN1; SMN2
SCHEMBL10644141 0.81 CYP1A2 (0.53) LTA4HMAPK14RAB9ANPC1SMN1; SMN2
SCHEMBL1921438 0.81 LTA4H (0.56) LTA4HMAPK14RAB9ANPC1SMN1; SMN2
SCHEMBL10649038 0.80 MCHR1 (0.54) LTA4HMAPK14RAB9ANPC1SMN1; SMN2
SCHEMBL8326730 0.80 MCHR1 (0.54) LTA4HMAPK14RAB9ANPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0767790-B1 CONDENSED IMIDAZOLE COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2001-12-12 EP disclosed
CN-1046725-C fused imidazole compounds, their preparation and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1999-11-24 CN disclosed
US-5840732-A ANTIDIABETIC AGENTS, AUTOIMMUNE DISEASES OR IMMUNOSUPPRESSANTS TAKEDA CHEMICAL INDUSTRIES LTD. (JP) 1998-11-24 US disclosed
CN-1151161-A fused imidazole compounds, their preparation and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1997-06-04 CN disclosed
EP-0767790-A1 CONDENSED IMIDAZOLE COMPOUNDS, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1997-04-16 EP disclosed
WO-1995035296-A1 CONDENSED IMIDAZOLE COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-12-28 WO disclosed