Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.54 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10644419 | 1.00 | MCHR1 (0.54) | MCHR1TLR8CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10649038 | 1.00 | MCHR1 (0.54) | MCHR1TLR8CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10644141 | 0.98 | CYP1A2 (0.53) | MCHR1TLR8CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7222828 | 0.93 | CYP1A2 (0.59) | MCHR1TLR8CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1921438 | 0.87 | LTA4H (0.56) | MCHR1TLR8CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5999885 | 0.82 | PDE5A (0.51) | MCHR1TLR8CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL18970261 | 0.82 | LTA4H (0.54) | MCHR1CYP1A2CYP2C9CYP2C19LTA4H | |
| SCHEMBL7844990 | 0.82 | LTA4H (0.54) | MCHR1TLR8CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL31033074 | 0.82 | LTA4H (0.44) | MCHR1TLR8CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL28251707 | 0.81 | LMNA (0.51) | MCHR1TLR8CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730594-B1 | 9-HYDROXY-PYRIDO [1,2-a]PYRIMIDIN-4-ONE ETHER DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 1999-09-08 | — | — | EP | disclosed |
| US-5688799-A | NEUROTRANSMITTER ANTAGONIST | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-11-18 | — | — | US | disclosed |
| EP-0730594-A1 | NOVEL 9-HYDROXY-PYRIDO [1,2-a]PYRIMIDIN-4-ONE ETHER DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014691-A1 | NOVEL 9-HYDROXY-PYRIDO[1,2-a]PYRIMIDIN-4-ONE ETHER DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-06-01 | — | — | WO | disclosed |